Serotonin Neurons, Neuroplasticity, and Homeostasis of Neural Tissue

Serotonin and brain: evolution, neuroplasticity, and homeostasis.

Neurotransmitters are chemicals released by the presynaptic endings of neurons that have specialized actions through specific receptors on the membrane potential of postsynaptic neurons. However, these chemicals have more complex functions both within the neuron and on its varied cellular targets. These functions include changes in metabolic activities that have consequences on the plasticity o...

Serotonin buffers hippocampal neuroplasticity and emotional behavior

O23: Differentiation of Human Neural Stem-Like Cells Derived from Epileptic Amygdala Tissue into Motor Neurons

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Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets.

Neural stem cells (NSCs) offer special therapeutic prospects because they can be isolated from the CNS, expanded ex vivo, and re-implanted into diseased CNS where they not only migrate and differentiate according to cues from host tissue but also appear to be capable of affecting host cells. In nervous (nr) mutant mice Purkinje neuron (PN) mitochondria become abnormal by the second postnatal we...

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These receptors are attractive pharmacological targets for the treatment of obesity; however, the identity of the serotonin 2C receptor-expressing neurons that mediate the effects of serotonin and serotonin 2C receptor agonists on energy and glucose homeostasis are unknown. Here, we show that mice lacking serotonin ...